Blavatnik Institute
Genetics

Xiao Tian

Post-doctoral Fellow
Xiao Tian

Research Interest:

My general research interest is to understand how we age and how to delay aging. Previously I have found that DNA double strand break (DSB) repair is a positive co-evolving factor with lifespan by studying a group of short- and long-lived rodent species. My study in the Sinclair lab will focus on understanding the epigenetic consequences of DNA repair and their contribution to the aging process. Our data with the Inducible Changes in the Epigenome mouse model showed that epigenetic change is an important cause of aging. By defining the factors that are involved in epigenetic changes and resetting during and after DNA repair, we aim to develop strategies to promote the epigenetic resilience of the cell.